肖雪媛教授

基本信息

邮箱:xyxiao@bnu.edu.cn

主页:

实验室人员


发表文章

Zunlei Qian, Min Li, Rui Wang, Qianqian Xiao, Jing Wang, Mingying Li, Dacheng He*, and Xueyuan Xiao*. Knockdown of CABYR-a/b Increases Chemosensitivity of Human Non–Small Cell Lung Cancer Cells through Inactivation of Akt, Mol. Cancer Res., Mar 2014;12:335-347. (*corresponding authors).
Xiaojun Yang, Qianqian Xiao, Caixia Niu, Nan Jin, Jin Ouyang*, Xueyuan Xiao* &Dacheng He. Multifunctional core-shell upconversion nanoparticles for targeted tumor cells induced by near-infrared light. Journal of Materials Chemistry 2013,1: 2757-2763. (*corresponding authors).
J Hao, K Wang, Y Yue, T Tian, A Xu, J Hao, X Xiao*, and D He*. Selective expression of S100A11 in lung cancer and its role in regulating proliferation of adenocarcinomas cells. Mol Cell Biochem, 2012; 359(1-2): 323-332。(*corresponding authors)
Anjian Xu, Jia Hao, Zhao Zhang, Tian Tian, Chuanjun Liu, Xiaolei Xie, Lingyun Huang, Xueyuan Xiao* & Dacheng He*. 14kDa phosphohistidine phosphatase and its role in lung cancer migration and metastasis. Lung Cancer, 2010;67:48-56. (*corresponding authors)
Hao Zhang, Qian Zhao, Yue Chen, Yingping Wang, Shugeng Gao, Ying Mao, Mingying Li, An Peng, Dacheng He* & Xueyuan Xiao*. Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas. Thorax, 2008;63;352-359 (*corresponding authors)



研究方向

肿瘤发生和转移的蛋白质组学研究

采用蛋白质芯片、2D和质谱等技术筛选与肿瘤发生和转移相关的标志蛋白或功能蛋白,并利用分子生物学和细胞生物学等方法,探讨候选蛋白在肿瘤发生和发展中的作用以及分子机制和信号通路,可望为临床肿瘤的预警、诊断、治疗和新药靶筛选提供理论依据。

细胞周期调控的蛋白质组学研究

采用蛋白质组学技术研究细胞不同时相的蛋白质表达谱。筛选与细胞增殖、分化、凋亡相关的功能蛋白并研究其生物学功能。为阐明肿瘤发生机理、控制肿瘤转移及神经系统推行性疾病的治疗提供新的思路。