张伟副教授
邮箱：zhangwei@bnu.edu.cn
主页：
Zhang B, Wang O, Qin J, Liu S, Sun S, Liu H, Kuang J, Jiang G, Zhang W. cis-Acting Elements and trans-Acting Factors in the Transcriptional Regulation of Raf Kinase Inhibitory Protein Expression. PLoS One. 2013 Dec 26;8(12):e83097 (Correspondence Author)
Xiaocui Zhang, Qiuju Cao, Xiaodan Liu, Shuaishuai Liu, Juan Wang, Sheng Sun, Ou Wang, Zhihua Tian, Huitu Liu, Jian Kuang and Wei Zhang. Cellular and molecular evidence for malignancy inhibitory functions of p15RS.Cell Cycle. 2012;11(10):1988-1998 (Correspondence Author)
H. Xinzhou, Y. Ning, W. Ou, L. Xiaodan, Y. Fumin, L. Huitu, and Z. Wei. RKIP Inhibits the Migration and Invasion of Human Prostate Cancer PC-3M Cells through Regulation of Extracellular Matrix. Molecular Biology. 2011; 45( 6):921–928 (Correspondence Author)
Zhou J, Zhang W, Liang B, Casimiro MC, Whitaker-Menezes D, Wang M, Lisanti MP, Lanza-Jacoby S, Pestell RG, Wang C PPARgamma activation induces autophagy in breast cancer cells. Int J Biochem Cell Biol. 2009;41(11):2334-42（Cofirst Author）
Wei Zhang, Hui Tu Liu. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Research. 2002;12(1):9-18,
可逆磷酸化与细胞周期调控：可逆磷酸化是细胞周期调控的重要方式，我们的研究旨在阐明MAPK信号通路激酶调控细胞周期可逆磷酸化过程的分子机制。
p15RS对肿瘤细胞迁移及侵袭的影响及作用途径： p15RS是受p15INK4B正调的细胞核内蛋白，我们发现p15RS可以显著抑制人黑色素瘤细胞的锚定非依赖性生长及迁移和侵袭能力，我们的研究旨在揭示p15RS调控肿瘤细胞迁移和侵袭的分子途径。
RKIP上游信号调节通路的研究： Raf激酶抑制蛋白（RKIP）参与对Raf/MAPK，GPCR以及NF-κB等信号通路的调节，并与肿瘤等多种生理及病理过程密切相关，其表达调控途径有待进一步阐明。我们的研究重点在于从转录水平上阐明其在肿瘤细胞中表达下调的分子机制。